Dr. Sven Askes

Sven Askes

Contact
Phone: +49 3641 9 48 129 (Laboratory)
E-mail: s.h.c.askes[at]chem.leidenuniv.nl

Higher Education
Present                Postdoctoral Fellow in Dr. Schiller’s group
2012-2016           Leiden University, Netherlands, PhD
2010-2012           Leiden University, Netherlands, Master of Science
2007-2010           Leiden University and Technical University Delft, Netherlands, Bachelor of Science

Research topic
Switching the action spectrum of light-activatable metal complexes to the phototherapeutic window using photon upconversion

Publications
First author contributions

  1. S. H. C. Askes, A. Bahreman, and S. Bonnet. „Activation of a Photodissociative Ruthenium Complex by Triplet–Triplet Annihilation Upconversion in Liposomes.“ Angew. Chem., Int. Ed. 2014, 53, 1029.
  2. S. H. C. Askes and S. Bonnet. “Upconverting Vesicles and Uses” International Patent WO/2015/059180.
  3. S. H. C. Askes, N. López Mora, R. Harkes, R. I. Koning, B. Koster, T. Schmidt, A. Kros, and S. Bonnet. „Imaging the lipid bilayer of giant unilamellar vesicles using red-to-blue light upconversion.“ Chem. Commun. 2015, 51, 9137.
  4. S. H. C. Askes, M. Kloz, G. Bruylants, J. T. Kennis, and S. Bonnet. „Triplet-triplet annihilation upconversion followed by FRET for the red light activation of a photodissociative ruthenium complex in liposomes.“ Phys. Chem. Chem. Phys. 2015, 17, 27380.
  5. S. H. C. Askes, W. Pomp, S. L. Hopkins, A. Kros, S. Wu, T. Schmidt, and S. Bonnet. “Imaging upconverting polymerosomes in cancer cells: biocompatible anti-oxidants brighten triplet-triplet annihilation upconversion.” Small 2016, 12, 5579.
  6. S. H. C. Askes, M. S. Meijer, T. Bouwens, I. Landman, and S. Bonnet. “Photochemical activation of Ru(II) polypyridyl prodrugs through meat using triplet-triplet annihilation upconversion.” Molecules, 2016, 21, 1460.
  7. S. H. C. Askes, P. Brodie, G. Bruylants, and S. Bonnet. “Temperature dependence of triplet-triplet annihilation upconversion in phospholipid membranes.” J. Phys. Chem. B., 2017, DOI: 10.1021/acs.jpcb.6b10039.
  8. S. H. C. Askes, V. Leeuwenburgh, W. Pomp, S. Grecea, T. Schmidt, and S. Bonnet. “Silica-coating of upconverting liposomes for protection against quenching by oxygen.” ACS Biomater. Sci. Eng. 2017. In press.

Co-author contributions

  1. H. Adriaanse, S. H. C. Askes, Y. van Bree, S. van Oudheusden, E. D. van den Bos, E. Günay, I. Mutikainen, U. Turpeinen, G. A. van Albeda, J. G. Haasnoot, J. Reedijk. “Coordination chemistry of 5,6,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidine with first-row transition-metal salts: Synthesis, spectroscopy and single-crystal structures, with counter-anion dependence of the structures.” Polyhedron, 2009, 28, 3143.
  2. Liu, S. Akerboom, S. H. C. Askes, I. Mutikainen, and E. Bouwman. “A novel coordination network of Tb(III) with 2-hydroxy-trimesic acid showing very intense photoluminescence.” Inorg. Chem. Commun., 2015, 61, 60.
  3. Kong, S. H. C. Askes, S. Bonnet, A. Kros, and F. Campbell. (2016). „Temporal Control of Membrane Fusion through Photolabile PEGylation of Liposome Membranes.“ Angew. Chem., Int. Ed. 2016, 55, 1396.
  4. L. Hopkins, B. Siewert, S. H. C. Askes, P. van Veldhuizen, R. Zwier, M. Heger, and S. Bonnet. „In vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines.“ Photochem. Photobiol. Sci. 2016, 15, 644.
  5. A. Göttle, F. Alary, M. Boggio-Pasqua, I. M. Dixon, J.-L. Heully, A. Bahreman, S.H. C. Askes, and S. Bonnet. „Pivotal Role of a Pentacoordinate 3MC State on the Photocleavage Efficiency of a Thioether Ligand in Ruthenium(II) Complexes: A Theoretical Mechanistic Study.“ Inorg. Chem., 2016, 55, 4448.
  6. H. S. van Rixel, B. Siewert, S. L. Hopkins, S. H. C. Askes, A. Busemann, M. A. Siegler, and S. Bonnet. „Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites.“ Chem. Sci., 2016, 7, 4922.
  7. N. Lameijer, S. L. Hopkins, T. G. Brevé, S. H. C. Askes, and S. Bonnet. “L- versus D-glucose conjugation: Mitochondrial targeting of a light-activated dual-mode of action ruthenium-based anticancer prodrug.” Chem. Eur. J., 2016, DOI: 10.1002/chem.201603066.