Nitric oxide (NO) and carbon monoxide (CO) act as messenger molecules in the human body. NO- and CO-releasing materials (NORMAs & CORMAs) are important for the development of safe gasotransmitter delivering devices for therapeutic purposes; toxic metabolites after gas release are kept in the biocompatible polymer matrix. NO and CO photodonors use light as a convenient non-invasive on/off trigger since it allows the accurate control of site, timing and dosage. Here we report the concept of embedding water-insoluble, photoactive NO and CO metal complexes into nanoparticles and fibrous polymer non-wovens. NO and CO release into the surrounding medium is performed by light stimulation of the high surface area materials.Metal nitrosyl or carbonyl complexes were non-covalently embedded into the polymer matrices via miniemulsion technique or electrospinning.[4,6,7] Especially dimanganese decacarbonyl in electrospun poly(L-lactide-co-D/L-lactide) fibers revealed nanoporous morphologies. A slight CO release from the metal complex induced nanoporosity in the electrospinning process.[5,7] Irradiation with light between 366 and 480 nm in water triggered NO/CO release from the nanoparticles or non-wovens.[4-7] With CORMA the cytotoxicity tests with 3T3 mouse fibroblast cells in the dark revealed a very low mortality rate. After illumination, CO bubbled out of the nanofibers thereby eradicating fibroblast cell cultures or biofilms with methicilin-resistant Staphylococcus aureus (MRSA).
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